Rent the reasoning. Own the knowledge. HIP One, PES One, and CPS One run clinical operations, patient engagement, and compliance for 50+ enterprise platform clients — powered by the Healthcare Brain, the knowledge product that keeps your institutional knowledge compiled, current, and compounding.
Trusted by 50+ enterprise platform clients across payers, providers, and government — each buyable whole, by module, or as single agents.

Prior authorization, utilization management, medical review, payment integrity, and quality measurement on one AI-native platform. Live in CMS Medicare with Novitas in MAC JL.

Omnichannel patient and member interactions across voice, digital, and mobile — clinical-grade NLU on Microsoft HAS. Resolves, not just routes.

A complete privacy operating system plus AI Readiness, AI Risk, and AI policy enforcement. Most of CPS One uses no AI — by design.
Automate PA decisions, streamline medical review, meet CMS-0057-F requirements, and reduce delegated UM dependency — with a CMS-validated platform and a no-auto-deny architecture.
The payer path →
PES One resolves — not just routes — across voice, digital, and mobile: 16 health systems, 40–50% containment, 47% lower support cost.
The provider path →

The reference deployment is in production: CMS WISeR in New Jersey — the brain inside the perimeter, audit packets as build artifacts.
The government path →
The Healthcare Brain is a subscription knowledge product: a canonical, typed model of US healthcare — regulations, workflows, payers, populations — plus a private overlay that captures your institution's own knowledge. A factory keeps both current; read paths make them usable by every platform, agent, and analyst you run. The three platforms above are its flagship consumers.
In the full contract-lawyer sense. Compounding happens on your side of the boundary — it leaves with you if you leave.
The shared substrate is ours; the overlay is yours. Two layers, one schema.
Regulatory change absorbed on SLA, shipped as signed change manifests. Currency is a process, not a promise.
Eval pass rate, change latency, freshness — published, not claimed.
Agent Builders build on it. Forward-Deployed Engineers deploy with it. Domain Operators govern it. One context and semantic layer makes three roles one organization — ours today, yours in weeks.
WISeR — live since January 2026, serving 1M+ Medicare beneficiaries in New Jersey (MAC JL, Novitas). 25K+ authorizations processed cumulatively.


[Genzeon Platforms · PES One — "Patient experience, resolved."]
PES One: Good morning! Welcome to Duly Health and Care appointment management line. If this is an emergency, please hang up and dial 911.
Caller (Andrew, phone call): [States reason for call — appointment scheduling.]
PES One: [Verifies identity — name and date of birth.] That was July 13, 1995 — right?
Caller: Yes.
PES One: That was 212-568-3030, right?
Caller: Yes.
PES One: [Presents available appointments — January 27, 28, 29 · 8:00 AM, 8:30 AM, 9:00 AM, 10:00 AM, 12:00 PM · Matthew Medley, CRNP.] I've also got openings on the calendar.
PES One: So it'll be on Tuesday, January 27 at 8:30 AM with Matthew Medley, CRNP.
PES One: Should I send it to this number? Or you can provide another.
Caller: That's 660-528-5010.
PES One: [Confirmation sent by text.]
[Genzeon Platforms outro]
Sixty-second takes from the Building the Healthcare Brain podcast — conversations, not product demos. Platform-walkthrough slots stay open until those cuts publish; paste an ID into any card and it goes live (segment playback + VideoObject schema per G7-6/G7-7).


Agentic orchestration, clinical decision intelligence, workflow engine, integration, and deployment infrastructure. Six agents buyable individually on Microsoft Marketplace. Containment is a dial — set by classification, measured by KCI.

Full platform implementation, FDE-led. Starter transactable on Microsoft Marketplace; Professional & Enterprise by private offer.
See the motion →Risk-shared engagement against a measured operational outcome. The CMS WISeR model runs this way.
See the motion →Single agents from Microsoft Marketplace. From $100K per agent · 5–10 days to first decision.
See the agents →"CompliancePro is a tremendous timesaver to keep every busy Privacy Professional organized."
Genzeon Platforms is the agentic AI decision infrastructure for healthcare. It comprises three production platforms — HIP One for prior authorization and utilization management, PES One for patient and member engagement, and CPS One for privacy and AI governance. HIP One and PES One run on Aether One, a patent-protected agent architecture. Genzeon Platforms is in production with payers, providers, and government health programs today.
Yes. Genzeon Platforms is one of six commercially available PA platforms processing Medicare FFS prior authorizations under the CMS WISeR Model. It is the only WISeR participant available across all deployment environments (sovereign, government cloud, commercial cloud, on premises) and every consumption requirement (full platform, outcome-based, or individual agents). Genzeon Platforms is working with Novitas Solutions in the New Jersey market and went live January 2026.
Genzeon Platforms can be deployed in four shapes: sovereign (on customer infrastructure with Knowledge Containment Architecture), government cloud (FedRAMP-aligned, ATO-ready), commercial cloud (AWS, Azure, Google Cloud), and on-premises. The same code path supports all four targets — there is no cloud-only shortcut.
Yes. Genzeon Platforms supports five buying options: license the Healthcare Brain for your organization; buy HIP One, PES One, or CPS One as a complete SaaS platform (Marketplace-transactable Starter; enterprise tiers by private offer); buy individual agents on marketplaces (from $100K per agent per year); buy outcomes as Business Process as a Service, risk-shared and performance-based; or have Healthcare FDEs build custom agentic AI on the Brain. Agents live on Microsoft Azure Marketplace include the HIP One Medical Necessity Agent, the HIP One Prior Auth Eligibility and Pre-Screen Agent, and the HIP One Summarization Agent.
Aether One is the patent-protected agentic AI substrate underneath HIP One and PES One. It is not a single LLM wrapper — it is an orchestration and rule-grounded execution layer with deterministic guardrails, agent-level tools, and audit-grade traceability. The platform-spanning agent architecture is protected by 12 patents filed and more in preparation.
Most of CPS One uses no AI by design. The core privacy operations modules — incident management, breach notification, BAA tracking, disclosure accounting, policy enforcement, AI Readiness, and AI Risk Assessment — run on deterministic, rule-based workflows. The CPS Insights reporting module is the single exception; it uses Aether One for analytical pattern detection across aggregated reporting data only. PHI is never used for AI training. This scoping is contractual and architectural.
CMS-0057-F mandates electronic prior authorization via FHIR APIs for impacted payers (Medicare Advantage, Medicaid managed care, CHIP, QHP issuers on FFEs) by January 1, 2027. Public reporting of PA metrics began March 31, 2026. HIP One supports the full Da Vinci FHIR PA suite (CRD, DTR, PAS) production-ready today.
Genzeon Corporation is a healthcare AI and automation company headquartered in Exton, Pennsylvania. Genzeon Platforms is the platforms business of Genzeon Corporation, with its own leadership, engineering team, P&L, and patent portfolio. The platforms business has filed 12 patents covering the methodology layer of healthcare AI.
A healthcare AI agent is an autonomous software entity capable of clinical reasoning and task execution. Within the Genzeon Platforms ecosystem, these agents are powered by the Healthcare Brain to handle complex medical reviews and administrative workflows with human-level accuracy at machine speed.
On the CMS WISeR Innovation Model in Q1 2026, HIP One delivered sub-3-minute median decision latency on the auto-affirm path across 12,609 prior authorization cases — at 100% compliance with the federal three-day turnaround standard, well inside CMS-0057-F's 7-day standard and 72-hour expedited PA decision windows. By April 2026, sub-1-day turnaround on 90% of standard cases. These figures are drawn from operational logs, not benchmark estimates.
The Healthcare Brain is comprised of three specialized platforms: HIP One — the Reasoning Lobe for clinical decisioning (prior authorization, utilization management, claim review); PES One — the Engagement Lobe for patient and member interactions; and CPS One — the Prefrontal Cortex for governance, privacy, and AI-policy enforcement. All three run on Aether One, the patent-protected agentic substrate. 12 patents filed.
The Healthcare Brain is operated under ISO 27001, SOC 2 Type II, and HIPAA controls, with zero ONC fines on record across 40+ enterprise clients in regulated industries. CPS One — the Prefrontal Cortex — sits alongside the Reasoning and Engagement lobes as the governance counterweight, enforcing privacy lifecycle, AI Readiness Assessments, AI Risk Assessments, and continuous policy enforcement on every action the platform takes.
A standard LLM predicts text. The Healthcare Brain performs structured clinical reasoning. Unlike a general-purpose model, the Healthcare Brain uses specialized agents with deterministic guardrails and per-criterion citation chains, with every adverse determination requiring human clinician sign-off — ensuring patient safety, audit-grade traceability, and CMS-0057-F regulatory compliance.
"Our privacy team is enjoying the new assessment tool, which has streamlined our auditing process."
"The implementation of CPS One has been a significant time saver… transformed our privacy program."




12,609 PA cases · 100% three-day TAT · sub-1-day turnaround for 90% of standard cases by April 2026.
Read the WISeR case study →The payer's implementation playbook for CMS-0057-F.
Read →Monthly field notes by Harsh Singh, first Tuesday, on LinkedIn. And the open Academy — every FDE completes Builders Tracks 1–4 before customer engagement.
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